Research Group on Healthy Aging
Metabolism and Organic Damage Area
To know the molecular mechanisms involved in aging and frailty processes
To develop possible methods to evaluate them
To develop appropriate intervention strategies
To determine an index of quality of life in experimental animals
To develop human imaging biomarkers for the diagnosis of frailty
To study interventions to delay aging and prevent frailty
– Therapy with small extracellular vesicles
– Role of the antiapoptotic gene Bcl-xL
Coordinator
STAFF
Collaborating Researchers
Nurse
Technicians
Administrative assistant
Publications
Effects of mirror therapy on spasticity and sensory impairment after stroke: systematic review and meta-analysis. Munoz Gomez E, Ingles M, Aguilar Rodriguez M, Sempere Rubio N, Molla Casanova S, Serra Ano P. PM & R. 2023 Feb 14. doi: 10.1002/pmrj.12964. PMID: 36787183
Extracellular vesicles as therapeutic resources in the clinical environment. Sanz Ros J, Mas Bargues C, Romero Garcia N, Huete Acevedo J, Dromant M, Borras C. International Journal of Molecular Sciences. 2023 Jan 25;24(3):2344. doi: 10.3390/ijms24032344. PMID: 36768664
Extracellular Vesicles as Very Important Particles (VIPs) in Aging. Mas Bargues C, Alique M. International Journal of Molecular Sciences. 2023 Feb 20;24(4):4250. doi: 10.3390/ijms24044250. PMID: 36835661
Potential benefits of a single session of remote ischemic preconditioning and walking in sedentary older adults: a pilot study. Munoz-Gomez E, Molla-Casanova S, Sempere-Rubio N, Serra-Ano P, Aguilar-Rodriguez M, Alonso-Aubin DA, Chulvi-Medrano I, Ingles M. International Journal of Environmental Research and Public Health. 2023 Feb 16;20(4):3515. doi: 10.3390/ijerph20043515. PMID: 36834210
Blood DNA methylation patterns in older adults with evolving dementia. Fernandez Perez R, Alba Linares JJ, Tejedor JR, Fernandez Fernandez A, Calero M, Roman Dominguez A, Borras C, Vina J, Avila J, Medina M, Fernandez Fraga M. The journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 2022 Sep 1;77(9):1743-1749. doi: 10.1093/gerona/glac068. PMID: 35299244
Effect of a craniosacral therapy protocol in people with migraine: a randomized controlled trial. Munoz-Gomez E, Ingles M, Aguilar-Rodriguez M, Molla-Casanova S, Sempere-Rubio N, Serra-Ano P, Espi-Lopez G. Journal of Clinical Medicine. 2022 Jan 30;11(3):759. doi: 10.3390/jcm11030759. PMID: 35160211
Effects of foam rolling vs. manual therapy in patients with tension-type headache: a randomized pilot study. Espi-Lopez G, Ingles M, Carrasco-Fernandez J, Serra-Ano P, Copete-Fajardo L, Gonzalez-Gerez J, Saavedra-Hernandez M, Marques-Sule E. Journal of Clinical Medicine. 2022 Mar 23;11(7):1778. doi: 10.3390/jcm11071778. PMID: 35407385
Fourier analysis of collagen bundle orientation in myocardial infarction scars. Marcos-Garces V, Rios-Navarro C, Gomez-Torres F, Gavara J, de Dios E, Diaz A, Minana G, Chorro F, Bodi V, Ruiz-Sauri A. Histochemistry and Cell Biology. 2022 Nov;158(5):471-483. doi: 10.1007/s00418-022-02132-x. PMID: 35948735
Anti-inflammatory properties of diet: role in healthy aging.Stromsnes K, Correas A, Lehmann J, Gambini J, Olaso-Gonzalez G. Biomedicines. 2021 Jul 30;9(8):922. doi: 10.3390/biomedicines9080922. PMID: 34440125
Attitudes towards learning professional ethics in undergraduate physiotherapy students: A STROBE compliant cross-sectional study. Marques-Sule E, Arnal-Gomez A, Cortes-Amador S, de la Torre M, Hernandez D, Aguilar-Rodriguez M. Nurse Education Today. 2021 Mar;98:104771. doi: 10.1016/j.nedt.2021.104771. PMID: 33529858
Bcl-xL as a Modulator of Senescence and Aging. Mas-Bargues C, Borras C, Vina J. International Journal of Molecular Sciences. 2021 Feb 3;22(4):1527. doi: 10.3390/ijms22041527. PMID: 33546395
Bioengineered endometrial hydrogels with growth factors promote tissue regeneration and restore fertility in murine models. Lopez-Martinez S, Rodriguez-Eguren A, de Miguel-Gomez L, Frances-Herrero E, Faus A, Diaz A, Pellicer A, Ferrero H, Cervello I. Acta Biomaterialia. 2021 Nov;135:113-125. doi: 10.1016/j.actbio.2021.08.025. PMID: 34428563
BCL-xL, a Mitochondrial Protein Involved in Successful Aging: From C. elegans to Human Centenarians. Borras Blasco C, Mas Bargues C, Roman-Dominguez A, Sanz Ros J, Gimeno Mallench L, Inglés De La Torre M, Gambini Buchon J, Viña Ribes J. International Journal of Molecular Sciences. 2020 Jan 9;21(2):418. doi: 10.3390/ijms21020418. PMID: 31936510
Centenarians: An excellent example of resilience for successful ageing. Borras Blasco C, Inglés De La Torre M, Mas Bargues C, Dromant M, Sanz Ros J, Roman-Dominguez A, Gimeno Mallench L, Gambini Buchon J, Viña Ribes J. Mechanisms of Ageing and Development. 2020 Mar;186:111199. doi: 10.1016/j.mad.2019.111199. PMID: 31899226
Comparative study of the effectiveness of a low-pressure hyperbaric oxygen treatment and physical exercise in women with fibromyalgia: randomized clinical trial. Izquierdo-Alventosa R, Inglés De La Torre M, Cortes-Amador S, Gimeno Mallench L, Sempere Rubio N, Chirivella J, Serra Año M. Therapeutic advances in musculoskeletal disease. 2020 Jun 24;12:1759720X20930493. doi: 10.1177/1759720X20930493. PMID: 32636943
Development and Long-Term Follow-Up of an Experimental Model of Myocardial Infarction in Rabbits. Genovés Martínez P, Arias Mutis Ó, Parra Giraldo G, Such Miquel L, Zarzoso Muñoz M, Del Canto Serrano I, Soler Lopez C, Diaz Cuevas A, Blanch Torres E, Alberola Aguilar A, Such Belenguer L, Chorro Gascó F. Animals. 2020 Sep 4;10(9):1576. doi: 10.3390/ani10091576. PMID: 32899601
Projects
Title: Combining vitamin E-functionalized CHOcolate with physical exercise to reduce the risK of protein energy malnutrition in pre-dementia AGEd people. ERA-HDHL Call for Joint Transnational Research Proposals on Development of targeted nutrition for prevention of undernutrition for older adults (PREVNUT)
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: José Viña Ribes
Duration: 2021 – 2023
Total budget: 169.098 €
Title: Efecto del tratamiento con vesículas extracelulares de células madre de grasa de ratones jóvenes sobre parámetros de envejecimiento y fragilidad en ratones de edad avanzada
Funding body: Ministerio de Ciencia e Innovación
Principal Investigator: Consuelo Borrás Blasco
Duration: 2021 – 2024
Total budget: 181.500 €
Title: Estudio de posibles huellas genéticas de envejecimiento saludable en descendientes de centenarios
Funding body: Conselleria de Educación, Cultura y Deporte
Principal Investigator: Marta Inglés de la Torre
Duration: 2018 – 2019
Total budget: 12.040 €
Title: GUTMOM: Maternal obesity and cognitive dysfunction in the offspring: cause-effect role of the GUT MicrobiOMe and early dietary prevention
Funding body: European Commission. JPI HDHL
Principal Investigator: Patricia Lozzo
Duration: 2017 – 2020
Total budget: 778.240 €
Title: Obesidad materna y disfunción cognitiva en la descendencia: papel causa-efecto de la microbiota intestinal y prevención dietética temprana
Funding body: Ministerio de Economía y Competitividad
Principal Investigator: Consuelo Borrás Blasco
Duration: 2017 – 2022
Total budget: 143.000 €
Title: Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping
Funding body: European Commission
Principal Investigator: Erich Gnaiger
Duration: 2016 – 2020
Total budget:
+ Info
Doctoral candidate: Dromant Jarque, Mar
Director(s): Inglés De La Torre, Marta; Borrás Blasco, Consuelo; Viña Ribes, José
Date of the defense: 21/12/2021
University: Universitat de València
Title: Eficacia de la terapia manual en pacientes con migraña
Doctoral candidate: Muñoz Gómez, Elena
Director(s): Inglés De La Torre, Marta; Espí López, Gemma Victoria
Date of the defense: 23/04/2021
University: Universitat de València
Title: Efecto de la activación del receptor PPARy/RxR como posible tratamiento de la enfermedad de Alzheimer. Papel de la genisteína
Doctoral candidate: Muñoz Cebriá, José Enrique
Director(s): Viña, José; Borrás, Consuelo; Gambini, Juan
Date of the defense: 01/07/2020
University: Universitat de València
Title: Development of an ultrasound-based muscle texture analysis as a potential imaging biomarker for frailty phenotype
Doctoral candidate: Mirón Mombiela, Rebeca
Director(s): Borrás Blasco, Consuelo; Forner Giner, Juana
Date of the defense: 28/01/2019
University: Universitat de València